Pathanamthitta district is situated in the southern part of Kerala.

The headquarter of the district is in Pathanamthitta.

Three important rivers flow through the district.

The district is surrounded by Kottayam and Idukki districts in the north, Alappuzha district in the west, Kollam district in the south. To the east it borders the Tenkasi district of the Tamil Nadu state.

Devar Mala is the highest point in Pathnamthitta District.